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Ultra-conserved element : ウィキペディア英語版 | Ultra-conserved element An ultra-conserved element (UCE) is a region of DNA that is identical in at least two different species. One of the first studies of UCEs showed that human DNA sequences of length 200 nucleotides or greater were entirely conserved (identical nucleic acid sequence) in both rats and mice. Despite often being noncoding DNA, some ultra-conserved elements have been found to be transcriptionally active, giving non-coding RNA molecules. ==Evolution== Perfect conservation of these long stretches of DNA is thought to imply evolutionary importance as these regions appear to have experienced strong negative selection for 300-400 million years.〔〔 The probability of finding ultra-conserved elements by chance (under neutral evolution) has been estimated at less than 10−22 in 2.9 billion bases.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Ultra-conserved element」の詳細全文を読む
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